Our work
Top researchers from five institutions:
- Hong Kong University of Science and Technology
- Chinese University of Hong Kong
- Hong Kong University
- City University of Hong Kong
- Hong Kong Science and Technology Parks Corporation
Methods to study the epigenome
Tissue sample
processing
Clinical groups
(HKU, CUHK)
Purification of
primary cell-types
BioCRF Cell Sorting Facility
(HKUST)
Data
production
Mapping groups
(HKUST, CUHK, CityU)
Data processing &
deposition
Analysis groups
(CUHK, HKUST)
Cell sorting
DNA methylation
Histone modification
Transcription
Higher order chromatin structure
Cell sorting
FACS (Fluorescent activated cell sorting)
*Image from Abcam.com
DNA methylation
WGBS (Whole Genome Bisulfite Sequencing)
*Image from atdbio.com
Histone modification
ChIP-seq (Chromatin Immunoprecipitation)
*Image from GenomicWorks.com
Transcription
RNA-seq (Transcriptome sequencing)
*Image from Wikipedia
Higher order chromatin structure
HiC-seq is used to determine how chromatin (DNA+histones) fold up inside the cell
*Image from Nature Reviews
ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) investigates the accessibility of DNA within the cell
*Image from Nature Methods